研究業績 2020年

臨床をすべての中心として、ひとつひとつの症例を大切にしながら、日々研究に教育に勤しんでいます。その過程で、教室メンバーが関わってきた論文をご紹介します。

1. Eso Y, Nakano S, Mishima M, Arasawa S, Iguchi E, Takeda H, Takai A, Takahashi K, Seno H.

Branched-chain amino acid to tyrosine ratio is an essential pre-treatment factor for maintaining sufficient treatment intensity of lenvatinib in patients with hepatocellular carcinoma.
J Hepatobiliary Pancreat Sci. 2020 Dec;27(12):913-921.

2. Uchida Y, Masui T, Nagai K, Anazawa T, Yoshimura M, Uza N, Takaori K, Mizowaki T, Uemoto S.

Postoperative pancreatic fistulas decrease the survival of pancreatic cancer patients treated with surgery after neoadjuvant chemoradiotherapy: A retrospective analysis.
Surg Oncol. 2020 Dec;35:527-532.

3. Eso Y.

Microsatellite instability analysis using multiplex polymerase chain reaction with fluorescently labeled primers for amplification of five mononucleotide repeat markers.
Hepatol Res. 2020 Dec;50(12):1391-1392.

4. Iguchi E, Takai A, Takeda H, Kumagai K, Arasawa S, Eso Y, Shimizu T, Ueda Y, Marusawa H, Seno H.

DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis.
Sci Rep. 2020 Dec 4;10(1):21268.

5. Matsumori T, Kodama Y, Takai A, Shiokawa M, Nishikawa Y, Matsumoto T, Takeda H, Marui S, Okada H, Hirano T, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Kuriyama K, Sakuma Y, Ota Y, Maruno T, Uza N, Marusawa H, Kageyama R, Chiba T, Seno H.

Hes1 is essential in proliferating ductal cell-mediated development of intrahepatic cholangiocarcinoma.
Cancer Res. 2020 Dec 1;80(23):5305-5316.

6. Takeda H, Takai A, Kumagai K, Iguchi E, Arasawa S, Eso Y, Shimizu T, Ueda Y, Taura K, Uemoto S, Kita R, Haga H, Marusawa H, Fujimoto A, Seno H.

Multiregional whole-genome sequencing of hepatocellular carcinoma with nodule-in-nodule appearance reveals stepwise cancer evolution.
J Pathol. 2020 Dec;252(4):398-410.

7. Kawai M, Fukuda A, Yogo A, Kozu T, Taira K, Okuno T, Shirase T, Matsumoto A, Kawanami C, Seno H.

A case of a malignant serous neoplasm of the pancreas with synchronous vascular invasion and metachronous metastases.
Clin J Gastroenterol. 2020 Dec;13(6):1347-1354.

8. Matsumori T, Uza N, Okada H, Maruno T, Shiokawa M, Kodama Y, Seno H.

A novel technique for performing gallbladder tumor biopsy using a stent delivery system and biopsy forceps.
Endoscopy. 2020 Nov;52(11):E415-E417.

9. Utsumi T, Horimatsu T, Nishikawa Y, Teramoto A, Hirata D, Iwatate M, Sano Y, Seno H.

A short educational video to improve the accuracy of colorectal polyp size estimation: A multicenter prospective study.
Dig Endosc. 2020 Nov;32(7):1074-1081.

10. Iwai　T, Yoshimura M, Ashida R, Goto Y, Kishi T, Itasaka S, Shibuya K, Kanai M, Masui T, Fukuda A, Isoda H, Hiraoka M, Mizowaki T.

Hypofractionated Intensity-Modulated Radiotherapy with Concurrent Chemotherapy for Elderly Patients with Locally Advanced Pancreatic Carcinoma.
Radiat Oncol. 2020 Nov 13;15(1):264.

11. Morita T, Kodama Y, Shiokawa M, Kuriyama K, Marui S, Kuwada T, Sogabe Y, Matsumori T, Kakiuchi N, Tomono T, Mima A, Ueda T, Tsuda M, Yamauchi Y, Nishikawa Y, Sakuma Y, Ota Y, Maruno T, Uza N, Nagasawa T, Chiba T, Seno H.

CXCR4 in tumor epithelial cells mediates desmoplastic reaction in pancreatic ductal adenocarcinoma.
Cancer Res. 2020 Oct 1;80(19):4058-4070.

12. Hatoko T, Murakami T, Sone M, Yabe D, Masui T, Nakamoto Y, Furuta A, Uza N, Kodama Y, Harada N, Ogura M, Yasoda A, Inagaki N.

Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases.
Intern Med. 2020 Oct 1;59(19):2397-2403.

13. Notohara K, Kamisawa T, Fukushima N, Furukawa T, Tajiri T, Yamaguchi H, Aishima S, Fukumura Y, Hirabayashi K, Iwasaki E, Kanno A, Kasashima S, Kawashima A, Kojima M, Kubota K, Kuraishi Y, Mitsuhashi T, Naito Y, Naitoh I, Nakase H, Nishino T, Ohike N, Sakagami J, Shimizu K, Shiokawa M, Uehara T, Ikeura T, Kawa S, Okazaki K.

Guidance for diagnosing autoimmune pancreatitis with biopsy tissues.
Pathol Int. 2020 Oct;70(10):699-711.

14. Tolosa EJ, Fernandez-Barrena MG, Iguchi E, McCleary-Wheeler AL, Carr RM, Almada LL, Flores LF, Vera RE, Alfonse GW, Marks DL, Hogenson TL, Vrabel AM, Horn IP, Koenig AN, Safgren SL, Sigafoos AN, Erkan M, Romecin-Duran PA, Sarabia Gonzalez A, Zhou B, Javelaud D, Marsaud V, Graham RP, Mauviel A, Elsawa SF, Fernandez-Zapico ME.

GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression.
Biochem J. 2020 Sep 18;477(17):3131-3145.

15. Ogiso S, Seo S, Eso Y, Yoh T, Kawai T, Okumura S, Ishii T, Fukumitsu K, Taura K, Seno H, Uemoto S.

Laparoscopic liver resection versus percutaneous radiofrequency ablation for small hepatocellular carcinoma.
HPB (Oxford). 2020 Sep 7:S1365-182X(20)31122-9.

16. Yamauchi Y, Kodama Y, Shiokawa M, Kakiuchi N, Marui S, Kuwada T, Sogabe Y, Tomono T, Mima A, Morita T, Matsumori T, Ueda T, Tsuda M, Nishikawa Y, Kuriyama K, Sakuma Y, Ota Y, Maruno T, Uza N, Masuda A, Tatsuoka H, Yabe D, Minamiguchi S, Masui T, Inagaki N, Uemoto S, Chiba T, Seno H.

Rb and p53 execute distinct roles in the development of pancreatic neuroendocrine tumors.
Cancer Res. 2020 Sep 1;80(17):3620-3630.

17. Shiokawa M, Seno H, Kodama Y, Chiba T.

Disease severity is linked to an increase in autoantibody diversity in IgG4-related disease: comment on the article by Liu H et al.
Arthritis Rheumatol. 2020 Sep;72(9):1584-1585.

18. Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J.

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression.
Cancer Cell. 2020 Aug 10;38(2):247-262.

19. Marui S, Uza N, Yamazaki H, Ota S, Nakamura T, Yoshida H, Okada H, Hirano T, Kuwada T, Sogabe Y, Tomono T, Matsumori T, Morita T, Nishikawa Y, Tsuda M, Maruno T, Shiokawa M, Kodama Y, Seno H.

Utility of laser-cut covered self-expandable metal stents for unresectable malignant distal biliary obstruction: a single-center experience.
Endoscopy. 2020 Aug;52(8):664-668.

20. Ogawa S, Fukuda A, Matsumoto Y, Hanyu Y, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Yoshikawa T, Goto N, Hiramatsu Y, Tsuda M, Maruno T, Nakanishi Y, Hussein MS, Tsuruyama T, Takaori K, Uemoto S, Seno H.

SETDB1 Inhibits p53-Mediated Apoptosis and is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.
Gastroenterology. 2020 Aug;159(2):682-696.

21. Eso Y, Seno H.

Current status of treatment with immune checkpoint inhibitors for gastrointestinal, hepatobiliary, and pancreatic cancers.
Therap Adv Gastroenterol. 2020 Aug 21;13:1756284820948773.

22. Kikuchi S, Imai H,Tani Y, Tajiri T, Watanabe N.

Proton pump inhibitors for chronic obstructive pulmonary disease.
Cochrane Database Syst Rev. 2020 Aug 25;8:CD013113.

23. Min J, Han TS, Sohn Y, Shimizu T, Choi B, Bae SW, Hur K, Kong SH, Suh YS, Lee HJ, Kim JS, Min JK, Kim WH, Kim VN, Choi E, Goldenring JR, Yang HK.

microRNA-30a arbitrates intestinal-type early gastric carcinogenesis by directly targeting ITGA2.
Gastric Cancer. 2020 Jul;23(4):600-613.

24. Nishikawa Y, Uza N, Matsumori T, Shiokawa M, Seno H.

Endoscopic stone extraction for choledocholithiasis with an ultra-slim endoscope via a gastrostomy after esophagectomy.
VideoGIE. 2020 Jun 24;5(9):404-406.

25. Bamba S, Sakemi R, Fujii T, Takeda T, Fujioka S, Takenaka K, Kitamoto H, Umezawa S, Sakuraba H, Inokuchi T, Fukata N, Mizuno S, Yamashita M, Shinzaki S, Tanaka H, Takedatsu H, Ozaki R, Moriya K, Ishii M, Kinjo T, Ozeki K, Ooi M, Hayashi R, Kakimoto K, Shimodate Y, Kitamura K, Yamada A, Sonoda A, Nishida Y, Yoshioka K, Ashizuka S, Takahashi F, Shimokawa T, Kobayashi T, Andoh A, Hibi T.

A nationwide, multi-center, retrospective study of symptomatic small bowel stricture in patients with Crohn's disease
J Gastroenterol. 2020 Jun;55(6):615-626.

26. Zhu Y, Cui G, Miyauchi E, Nakanishi Y, Mukohira H, Shimba A, Abe S, Tani-Ichi S, Hara T, Nakase H, Chiba T, Sehara-Fujisawa A, Seno H, Ohno H, Ikuta K.

Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intraepithelial lymphocytes in the intestine.
Int Immunol. 2020 May 8;32(5):307-319.

27. Ueda T, Kumagai A, Iriguchi S, Yasui Y, Miyasaka T, Nakagoshi K, Nakane K, Saito K, Takahashi M, Sasaki A, Yoshida S, Takasu N, Seno H, Uemura Y, Tamada K, Nakatsura T, Kaneko S.

Non-clinical efficacy, safety, and stable clinical cell processing of iPSC-derived anti-GPC3 CAR-expressing NK/ILC cells.
Cancer Sci. 2020 May;111(5):1478-1490.

28. Minaga K, Watanabe T, Arai Y, Shiokawa M, Hara A, Yoshikawa T, Kamata K, Yamashita K, Kudo M.

Activation of interferon regulatory factor 7 in plasmacytoid dendritic cells promotes experimental autoimmune pancreatitis.
J Gastroenterol. 2020 May;55(5):565-576.

29. Hirohashi K, Ohashi S, Amanuma Y, Nakai Y, Ida T, Baba K, Mitani Y, Mizumoto A, Yamamoto Y, Kikuchi O, Matsubara J, Yamada A, Miyamoto S, Seno H, Matsuda T, Muto M.

Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice.
Carcinogenesis. 2020 Apr 22;41(2):194-202.

30. Sawada K, Takai A, Yamada T, Araki O, Yamauchi Y, Eso Y, Takahashi K, Shindo T, Sakurai T, Ueda Y, Seno H.

Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis.
Intern Med. 2020 Apr 15;59(8):1035-1040.

31. Teramoto A, Aoyama N, Ebisutani C, Matsumoto T, Machida H, Yoshida S, Uchima N, Utsumi T, Tochio T, Hirata D, Iwatate M, Hattori S, Fujita M, Sano W, Sano Y.

Clinical importance of cold polypectomy during the insertion phase in the left side of the colon and rectum: a multicenter randomized controlled trial (PRESECT study).
Gastrointest Endosc. 2020 Apr;91(4):917-924.

32. Nakano S, Eso Y, Okada H, Takai A, Takahashi K, Seno H.

Recent Advances in Immunotherapy for Hepatocellular Carcinoma.
Cancers (Basel). 2020 Mar 25;12(4):775.

33. Chen R, Sugiyama A, Kataoka N, Sugimoto M, Yokoyama S, Fukuda A, Takaishi S, Seno H.

Promoter-Level Transcriptome Identifies Stemness Associated With Relatively High Proliferation in Pancreatic Cancer Cells.
Front Oncol. 2020 Mar 20;10:316.

34. Ikuta K, Ota Y, Kuroki S, Matsumoto Y, Senda E, Mukohara S, Takahashi S, Monden K, Fukuda A, Seno H, Kumagai S, Shio S.

Development of Disseminated Tuberculosis with Intestinal Involvement due to Adalimumab Administration Despite Latent Tuberculosis Treatment.
Intern Med. 2020 Mar 15;59(6):849-853.

35. Kato Y, Azuma K, Someda H, Shiokawa M, Chiba T.

Case of IgG4-associated sclerosing cholangitis with normal serum IgG4 concentration, diagnosed by anti-laminin 511-E8 antibody: a novel autoantibody in patients with autoimmune pancreatitis.
Gut. 2020 Mar;69(3):607-609.

36. Morita T, Matsumori T, Uza N.

Gallbladder carcinoma associated with unique distribution of intraductal papillary neoplasm of bile duct accompanied by pancreaticobiliary maljunction.
Dig Endosc. 2020 Mar;32(3):432.

37. Suminaga K, Murakami T, Yabe D, Sone M, Sugawa T, Masui T, Uza N, Yoshizawa A, Ogura M, Yasoda A, Inagaki N.

Factory-calibrated continuous glucose monitoring and capillary blood glucose monitoring in a case with insulinoma: usefulness and possible pitfall under chronic hyperinsulinemic hypoglycemia.
Endocr J. 2020 Mar 28;67(3):361-366.

38. Nishikawa Y, Horimatsu T, Nishizaki D, Kohno A, Yokoyama A, Yoshioka M, Hida K, Sakanaka K, Minamiguchi S, Seno H, Sakai Y, Nakayama T.

Qualitative and Quantitative Analysis of Posttreatment Strategy After Endoscopic Resection for Patients with T1 Colorectal Cancer at High Risk of Lymph Node Metastasis.
J Gastrointest Cancer. 2020 Mar;51(1):242-249.

39. Kurita A, Yasukawa S, Zen Y, Yoshimura K, Ogura T, Ozawa E, Okabe Y, Asada M, Nebiki H, Shigekawa M, Ikeura T, Eguchi T, Maruyama H, Ueki T, Itonaga M, Hashimoto S, Shiomi H, Minami R, Hoki N, Takenaka M, Itokawa Y, Uza N, Hashigo S, Yasuda H, Takada R, Kamada H, Kawamoto H, Kawakami H, Moriyama I, Fujita K, Matsumoto H, Hanada K, Takemura T, Yazumi S.

Comparison of a 22-gauge Franseen-tip needle with a 20-gauge forward-bevel needle for the diagnosis of type 1 autoimmune pancreatitis: a prospective, randomized, controlled, multicenter study (COMPAS study).
Gastrointest Endosc. 2020 Feb;91(2):373-381.

40. Morita M, Ogawa C, Omura A, Noda T, Kubo A, Matsunaka T, Tamaki H, Shibatoge M, Seno H, Minami Y, Ueshima K, Sakurai T, Nishida N, Kudo M.

The Efficacy of Sonazoid-enhanced Ultrasonography in Decision-making for Liver Abscess Treatment.
Intern Med. 2020 Feb 15; 59(4): 471?477.

41. Yamashita T, Takeda H, Takai A, Arasawa S, Nakamura F, Mashimo Y, Hozan M, Ohtsuru S, Seno H, Ueda Y, Sekine A.

Single-molecular real-time deep sequencing reveals the dynamics of multi-drug resistant haplotypes and structural variations in the hepatitis C virus genome.
Sci Rep. 2020 Feb 14;10(1):2651.

42. Kikuchi S, Oe Y, Sasaki Y, Ishii H, Ito Y, Horikoshi M, Sozu T, Seno H, Furukawa TA.

Group cognitive behavioural therapy (GCBT) versus treatment as usual (TAU) in the treatment of irritable bowel syndrome (IBS): a study protocol for a randomized controlled trial.
BMC Gastroenterol. 2020 Feb 4;20(1):29.

43. Nam NH, Taura K, Kanai M, Fukuyama K, Uza N, Maeda H, Yutaka Y, Chen-Yoshikawa TF, Muto M, Uemoto S.

Unexpected metastasis of intraductal papillary neoplasm of the bile duct without an invasive component to the brain and lungs: A case report.
World J Gastroenterol. 2020 Jan 21;26(3):366-374.

44. Honzawa Y, Matsuura M, Higuchi H, Sakurai T, Seno H, Nakase H.

A novel endoscopic imaging system for quantitative evaluation of colonic mucosal inflammation in patients with quiescent ulcerative colitis.
Endosc Int Open. 2020 Jan;8(1):E41-E49.

45. Eso Y, Shimizu T, Takeda H, Takai A, Marusawa H.

Microsatellite instability and immune checkpoint inhibitors: toward precision medicine against gastrointestinal and hepatobiliary cancers.
J Gastroenterol. 2020 Jan;55(1):15-26.

46. Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S, Matsuura M, Horimatsu T, Hirano T, Goto N, Takeuchi Y, Ochi Y, Shiozawa Y, Kogure Y, Watatani Y, Fujii Y, Kim SK, Kon A, Kataoka K, Yoshizato T, Nakagawa MM, Yoda A, Nanya Y, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Sugihara E, Sato TA, Maruyama T, Miyoshi H, Taketo MM, Oishi J, Inagaki R, Ueda Y, Okamoto S, Okajima H, Sakai Y, Sakurai T, Haga H, Hirota S, Ikeuchi H, Nakase H, Marusawa H, Chiba T, Takeuchi O, Miyano S, Seno H, Ogawa S.

Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.
Nature. 2020 Jan;577(7789):260-265.

47. Utsumi T, Nakanishi Y, Minamiguchi S, Miyamoto S.

Solitary Colorectal Metastasis from a Mucin-rich Ovarian Tumor.
Intern Med. 2020 Jan 1;59(1):135-136.

48. Utsumi T, Higuchi H, Miyamoto S.

New endoscopic tattooing technique using sodium alginate solution.
Dig Endosc. 2020 Jan;32(1):147.

49. Shimizu T, Sohn Y, Choi E, Petersen CP, Prasad N, Goldenring JR.

Decrease in MiR-148a Expression During Initiation of Chief Cell Transdifferentiation.
Cell Mol Gastroenterol Hepatol. 2020;9(1):61-78.

50. Namikawa M, Kimura T, Fukuda A.

A Pancreatic Tumor with Central Calcification.
Japanese J Gastroenterol Hepatol. 2020;3(5):1-2.

51. Ueno Y, Seno H.

Steeper steps and pledge for inevitable responsibilities.
J Gastroenterol. 2020 Jan;55(1):1-3.