研究業績 2019年

臨床をすべての中心として、ひとつひとつの症例を大切にしながら、日々研究に教育に勤しんでいます。その過程で、教室メンバーが関わってきた論文をご紹介します。

1. Eso Y, Nakano S, Mishima M, Arasawa S, Iguchi E, Nakamura F, Takeda H, Takai A, Takahashi K, Taura K, Seno H.

Dose Intensity/Body Surface Area Ratio is a Novel Marker Useful for Predicting Response to Lenvatinib against Hepatocellular Carcinoma.
Cancers (Basel). 2019 Dec 22;12(1). E49.

2. Quy PN, Kanai M, Fukuyama K, Kou T, Kondo T, Yamamoto Y, Matsubara J, Hiroshima A, Mochizuki H, Sakuma T, Kamada M, Nakatsui M, Eso Y, Seno H, Masui T, Takaori K, Minamiguchi S, Matsumoto S, Muto M.

Association Between Preanalytical Factors and Tumor Mutational Burden Estimated by Next-Generation Sequencing-Based Multiplex Gene Panel Assay.
Oncologist. 2019 Dec;24(12):e1401-e1408.

3. Nishikawa Y, Hirata A, Uza N.

Hepatobiliary and Pancreatic: Intrahepatic cholangiocarcinoma with intratumoral calcification mimicking hepatolithiasis.
J Gastroenterol Hepatol. 2019 Dec;34(12):2060.

4. Watatani Y, Sato Y, Miyoshi H, Sakamoto K, Nishida K, Gion Y, Nagata Y, Shiraishi Y, Chiba K, Tanaka H, Zhao L, Ochi Y, Takeuchi Y, Takeda J, Ueno H, Kogure Y, Shiozawa Y, Kakiuchi N, Yoshizato T, Nakagawa MM, Nanya Y, Yoshida K, Makishima H, Sanada M, Sakata-Yanagimoto M, Chiba S, Matsuoka R, Noguchi M, Hiramoto N, Ishikawa T, Kitagawa J, Nakamura N, Tsurumi H, Miyazaki T, Kito Y, Miyano S, Shimoda K, Takeuchi K, Ohshima K, Yoshino T, Ogawa S, Kataoka K.

Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling.
Leukemia. 2019 Dec;33(12):2867-2883.

5. Mishima M, Sakurai T, Miyamoto S.

Intramucosal Metastasis of Gastric Cancer to the Duodenum.
Clin Gastroenterol Hepatol. 2019 Dec;17(13):A27.

6. Nakanishi Y, Diaz-Meco MT, Moscat J.

Serrated Colorectal Cancer: The Road Less Travelled ?
Trends Cancer. 2019 Nov;5(11):742-754.

7. Matsumoto Y, Nakanishi Y, Yoshioka T, Yamaga Y, Masuda T, Fukunaga Y, Sono M, Yoshikawa T, Nagao M, Araki O, Ogawa S, Goto N, Hiramatsu Y, Breyer RM, Fukuda A, Seno H.

Epithelial EP4 plays an essential role in maintaining homeostasis in colon.
Sci Rep. 2019 Oct 23;9(1):15244.

8. Nakamura T, Shiokawa M, Nakai Y.

Successful Hemostasis of Bleeding From Biliary Varices.
Clin Gastroenterol Hepatol. 2019 Oct;17(11):e130.

9. Kitamoto H, Inoue S, Okamoto K, Inokuma T.

Scanning early catches the worm: abdominal ultrasound as a possible screening method for intestinal cestodes.
Lancet. 2019 Oct 5;394(10205):1264.

10. Utsumi T, Horimatsu T, Seno H.

Measurement bias of colorectal polyp size: An analysis of the Japan Endoscopy Database.
Dig Endosc. 2019 Sep;31(5):589.

11. Hashimoto S, Furukawa S, Hashimoto A, Tsutaho A, Fukao A, Sakamura Y, Parajuli G, Onodera Y, Otsuka Y, Handa H, Oikawa T, Hata S, Nishikawa Y, Mizukami Y, Kodama Y, Murakami M, Fujiwara T, Hirano S, Sabe H.

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer.
Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17450-17459.

12. Chen R, Sugiyama A, Seno H, Sugimoto M.

Identification of modules and functional analysis in CRC subtypes by integrated bioinformatics analysis.
PLoS One. 2019 Aug 30;14(8):e0221772.

13. Takeda H, Yamashita T, Ueda Y, Sekine A.

Exploring the hepatitis C virus genome using single molecule real-time sequencing.
World J Gastroenterol. 2019 Aug 28;25(32):4661-4672.

14. Okada H, Izumi T, Uza N.

Granular Cell Tumor of the Bile Duct.
J Gastrointest Surg. 2019 Aug;23(8):1701-1703.

15. Kitamoto H, Fukushima M, Inokuma T.

Chronic GI bleeding in a middle-aged woman.
Gut. 2019 Aug;68(8):1385-1429.

16. Yoshikawa T, Kadokawa Y, Ohana M, Fukuda A, Seno H.

A Rare Case of Lymph Node Metastasis from Early Gastric Cancer.
Clin Endosc. 2019 Jul;52(4):369-372.

17. Ueda Y, Kobayashi T, Ikegami T, Miuma S, Mizuno S, Akamatsu N, Takaki A, Ishigami M, Takatsuki M, Sugawara Y, Maehara Y, Uemoto S, Seno H.

Efficacy and safety of glecaprevir and pibrentasvir treatment for 8 or 12 weeks in patients with recurrent hepatitis C after liver transplantation: a Japanese multicenter experience.
J Gastroenterol. 2019 Jul;54(7):660-666.

18. Kim SK, Takeda H, Takai A, Matsumoto T, Kakiuchi N, Yokoyama A, Yoshida K, Kaido T, Uemoto S, Minamiguchi S, Haga H, Shiraishi Y, Miyano S, Seno H, Ogawa S, Marusawa H.

Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis.
J Gastroenterol. 2019 Jul;54(7):628-640.

19. Funakoshi T, Miyamoto S, Kakiuchi N, Nikaido M, Setoyama T, Yokoyama A, Horimatsu T, Yamada A, Torishima M, Kosugi S, Yamada H, Sugimura H, Haga H, Sakai Y, Ogawa S, Seno H, Muto M, Chiba T.

Genetic analysis of a case of Helicobacter pylori-uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer.
Gastric Cancer. 2019 Jul;22(4):892-898.

20. Kataoka K, Miyoshi H, Sakata S, Dobashi A, Couronne L, Kogure Y, Sato Y, Nishida K, Gion Y, Shiraishi Y, Tanaka H, Chiba K, Watatani Y, Kakiuchi N, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Sanada M, Onozawa M, Teshima T, Yoshiki Y, Ishida T, Suzuki K, Shimada K, Tomita A, Kato M, Ota Y, Izutsu K, Demachi-Okamura A, Akatsuka Y, Miyano S, Yoshino T, Gaulard P, Hermine O, Takeuchi K, Ohshima K, Ogawa S.

Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas.
Leukemia. 2019 Jul;33(7):1687-1699.

21. Goto N, Fukuda A, Yamaga Y, Yoshikawa T, Maruno T, Maekawa H, Inamoto S, Kawada K, Sakai Y, Miyoshi H, Taketo MM, Chiba T, Seno H.

Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells.
Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12996-13005.

22. Yoshioka T, Fukuda A, Araki O, Ogawa S, Hanyu Y, Matsumoto Y, Yamaga Y, Nakanishi Y, Kawada K, Sakai Y, Chiba T, Seno H.

Bmi1 marks gastric stem cells located in the isthmus in mice.
J Pathol. 2019 Jun;248(2):179-190.

23. Kitamoto H, Yamashita D, Inokuma T.

A Rare Tumor Disseminated to the Gastrointestinal Tract After Treatment for HIV-Associated Lymphoproliferative Disease.
Gastroenterology. 2019 Jun;156(8):2136-2138.

24. Sono M, Fukuda A, Seno H, Yazumi S.

Paraplegia as an initial manifestation of pancreatic cancer.
JGH Open. 2019 May 14;3(4):353-354.

25. Nishikawa Y, Kodama Y, Shiokawa M, Matsumori T, Marui S, Kuriyama K, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Ota Y, Maruno T, Uza N, Uesugi M, Kageyama R, Chiba T, Seno H.

Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis.
Oncogene. 2019 May;38(22):4283-4296.

26. Sano Y, Chiu HM, Li XB, Khomvilai S, Pisespongsa P, Co JT, Kawamura T, Kobayashi N, Tanaka S, Hewett DG, Takeuchi Y, Imai K, Utsumi T, Teramoto A, Hirata D, Iwatate M, Singh R, Ng SC, Ho SH, Chiu P, Tajiri H.

Standards of diagnostic colonoscopy for early-stage neoplasia: Recommendations by an Asian private group.
Dig Endosc. 2019 May;31(3):227-244.

27. Eso Y, Kou T, Nagai H, Kim YH, Kanai M, Matsumoto S, Mishima-Iwai M, Arasawa S, Iguchi E, Nakamura F, Takeda H, Takai A, Takahashi K, Ueda Y, Muto M, Seno H.

Utility of ultrasound-guided liver tumor biopsy for next generation sequencing-based clinical sequencing.
Hepatol Res. 2019 May;49(5):579-589.

28. Nakamura T, Oe N, Matsumori T.

A Hypervascular Mass at the Papilla of Vater.
Gastroenterology. 2019 May;156(6):e7-e9.

29. Takai A, Dang H, Oishi N, Khatib S, Martin SP, Dominguez DA, Luo J, Bagni R, Wu X, Powell K, Ye QH, Jia H, Qin LX, Chen J, Mitchell GA, Luo X, Thorgeirsson SS, Wang XW.

Genome-wide RNAi Screen identifies PMPCB as a therapeutic vulnerability in EpCAM+ hepatocellular carcinoma.
Cancer Res. 2019 May 1;79(9):2379-2391.

30. Tomlinson A, Efthimiou O, Boaden K, New E, Mather S, Salanti G, Imai H, Ogawa Y, Tajika A, Kishimoto S, Kikuchi S, Chevance A, Furukawa TA, Cipriani A.

Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis.
Evid Based Ment Health. 2019 May;22(2):61-66.

31. Ikuta K, Fukuda A, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Tsuda M, Kimura Y, Matsumoto Y, Kimura Y, Maruno T, Kanda K, Nishi K, Takaori K, Uemoto S, Takaishi S, Chiba T, Nishi E, Seno H.

Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.
Gut. 2019 May;68(5):882-892.

32. Utsumi T, Yamada A, Sakurai T, Miyamoto S.

Rectal Submucosal Tumor Mimicking a Neuroendocrine Tumor.
Intern Med. 2019 May 15;58(10):1521-1522.

33. Sono M, Fukuda A, Seno H, Yazumi S.

Gastric Cancer from a Hyperplastic Polyp on an Endoscopic Submucosal Dissection Scar.
Intern Med. 2019 Apr 15;58(8):1179-1180.

34. Kagebayashi S, Yamamoto S, Seno H.

Jejunal diaphragm disease associated with cytomegalovirus infection.
Endosc Int Open. 2019 Apr;7(4):E533-E536.

35. Eso Y, Takai A, Takahashi K, Ueda Y, Taura K, Marusawa H, Seno H.

Combination of Mac-2 Binding Protein Glycosylation Isomer and Up-To-Seven Criteria as a Useful Predictor for Child-Pugh Grade Deterioration after Transarterial Chemoembolization for Hepatocellular Carcinoma.
Cancers (Basel). 2019 Mar 22;11(3): E405.

36. Jo N, Sogabe Y, Yamada Y, Ukai T, Kagawa H, Mitsunaga K, Woltjen K, Yamada Y.

Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling.
Cancer Sci. 2019 Mar;110(3):926-938.

37. Kotani S, Yoda A, Kon A, Kataoka K, Ochi Y, Shiozawa Y, Hirsch C, Takeda J, Ueno H, Yoshizato T, Yoshida K, Nakagawa MM, Nannya Y, Kakiuchi N, Yamauchi T, Aoki K, Shiraishi Y, Miyano S, Maeda T, Maciejewski JP, Takaori-Kondo A, Ogawa S, Makishima H.

Molecular pathogenesis of disease progression in MLL-rearranged AML.
Leukemia. 2019 Mar;33(3):612-624.

38. Mishima M, Horimatsu T, Miyamoto S.

Acute Respiratory Failure During Systemic Chemotherapy.
Gastroenterology. 2019 Mar;156(4):e7-e9.

39. Yamamoto S, Matsumura K, Seno H.

Segmental xanthomatosis of the ileum.
Clin Gastroenterol Hepatol. 2019 Feb;17(3):e18.

40. Kitamoto H, Kataoka T, Yamamoto S.

Multiple Polypoid Lesions in the Ileum After Treatment for Primary Ileal Follicular Lymphoma.
Gastroenterology. 2019 Feb;156(3):552-553.

41. Polprasert C, Takeuchi Y, Kakiuchi N, Yoshida K, Assanasen T, Sitthi W, Bunworasate U, Pirunsarn A, Wudhikarn K, Lawasut P, Uaprasert N, Kongkiatkamon S, Moonla C, Sanada M, Akita N, Takeda J, Fujii Y, Suzuki H, Nannya Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Rojnuckarin P, Ogawa S, Makishima H.

Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma.
Blood Adv. 2019 Feb 26;3(4):588-595.

42. Utsumi T, Hiramatsu Y, Miyamoto S.

Double ileocecal valve.
Gastrointest Endosc. 2019 Jan;89(1):201-202.

43. Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H.

Arid1a is essential for intestinal stem cells through Sox9 regulation.
Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1704-1713.

44. Yokoyama A, Kakiuchi N, Yoshizato T, Nannya Y, Suzuki H, Takeuchi Y, Shiozawa Y, Sato Y, Aoki K, Kim SK, Fujii Y, Yoshida K, Kataoka K, Nakagawa MM, Inoue Y, Hirano T, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Nishikawa Y, Amanuma Y, Ohashi S, Aoyama I, Horimatsu T, Miyamoto S, Tsunoda S, Sakai Y, Narahara M, Brown JB, Sato Y, Sawada G, Mimori K, Minamiguchi S, Haga H, Seno H, Miyano S, Makishima H, Muto M, Ogawa S.

Age-related remodelling of oesophageal epithelia by mutated cancer drivers.
Nature. 2019 Jan;565(7739):312-317.

45. Yoshiji S, Takahashi K, Sawada K, Mishima M, Eso Y, Morita M, Takai A, Marusawa H, Ueda Y, Mimori T, Seno H.

Accelerated Progression of Hepatocellular Carcinoma during Immunosuppressive Therapy with Abatacept for Rheumatoid Arthritis.
Intern Med. 2019 Jan 1;58(1):67-71.

46. Tsuda M, Fukuda A, Takaori K, Seno H.

Genetics and biology of pancreatic cancer and its precursor lesions: lessons learned from human pathology and mouse models.
Annals of Pancreatic Cancer 2019;2:15.

47. Setoyama T, Miyamoto S, Nikaido M, Seno H.

New Perspectives in Gastric Cancer: Helicobacter pylori-Uninfected Pure Signet Ring Cell Carcinoma.
Alcoholic/Non-Alcoholic Digestive Diseases, Springer, 33-41, 2019.