研究業績 2023年

臨床をすべての中心として、ひとつひとつの症例を大切にしながら、日々研究に教育に勤しんでいます。その過程で、教室メンバーが関わってきた論文をご紹介します。

1. Agatsuma N, Utsumi T, Higuchi H, Inoue T, Tanaka Y, Nakanishi Y, Seno H.

Novel removable endoscopic clip: Usefulness in failure of traction method during endoscopic submucosal dissection.
Endoscopy. 2023 Dec;55(S 01):E1031-E1032.

2. Inoue T, Katada C, Shimizu T, Nikaido M, Higuchi H, Kishimoto Y, Muto M.

Endoscopic resection combined with gel immersion and curved laryngoscope for superficial hypopharyngeal cancer.
Endoscopy. 2023 Dec;55(S 01):E831-E832.

3. Yasuda M, Matsumori T, Uza N, Shiokawa M, Maruno T, Okada H, Seno H.

Additional stenting for hilar cholangiocarcinoma using a novel delivery device after uncovered metallic stent placements.
Endoscopy. 2023 Dec;55(S 01):E521-E522.

4. Inoue T, Utsumi T, Agatsuma N, Nishikawa Y, Soshi M, Sano Y, Seno H.

A novel endoscopy training system by video-based asynchronous communication.
Endoscopy. 2023 Dec;55(S 01):E307-E309.

5. Muta Y, Linares JF, Martinez-Ordonez A, Duran A, Cid-Diaz T, Kinoshita H, Zhang X, Han Q, Nakanishi Y, Nakanishi N, Cordes T, Arora GK, Ruiz-Martinez M, Reina-Campos M, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, Garcia-Solano J, Conesa-Zamora P, Inghirami G, Metallo CM, Osborne TF, Diaz-Meco MT, Moscat J.

Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
Nat Commun. 2023 Dec 13;14(1):8075.

6. Xia Y, Cheng X, Nilsson T, Zhang M, Zhao G, Inuzuka T, Teng Y, Li Y, Anderson DE, Holdorf M, Liang TJ.

Nucleolin binds to and regulates transcription of hepatitis B virus covalently closed circular DNA minichromosome.
Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2306390120.

7. Matsuyama S, Fukuda A, Omatsu R, Nagao M, Okano A, Ueo T, Ohana M, Seno H.

A case of hepatic reactive lymphoid hyperplasia: the review of 23 cases from the literatures.
Clin J Gastroenterol. 2023 Dec;16(6):877-883.

8. Nikaido M, Takimoto T, Sakurai T, Hoki M, Minamiguchi S, Nakajima T, Torishima M, Nishigori T, Obama K, Koyama Y, Chiba T, Ushiama M, Gotoh M, Teramura M, Takeda H, Shimizu T, Seno H.

Gastric juvenile polyposis syndrome with inflammatory changes in the intervening mucosa.
Pathol Int. 2023 Nov;73(11):566-569.

9. Nagao M, Ueo T, Fukuda A, Ohana M.

Intraductal papillary mucinous carcinoma with co-mutations of KRAS/STK11.
BMJ Case Rep. 2023 Nov 27;16(11):e255945.

10. Shah VM, Rizvi S, Smith A, Tsuda M, Krieger M, Pelz C, MacPherson K, Eng J, Chin K, Munks MW, Daniel CJ, Al-Fatease A, Yardimci GG, Langer EM, Brody JR, Sheppard BC, Alani AW, Sears RC.

Micelle-Formulated Juglone Effectively Targets Pancreatic Cancer and Remodels the Tumor Microenvironment.
Pharmaceutics. 2023 Nov 21;15(12):2651.

11. Ueno M, Takabatake H, Kayahara T, Morimoto Y, Notohara K, Mizuno M.

Long-term outcomes of drug-induced autoimmune-like hepatitis after pulse steroid therapy.
Hepatol Res. 2023 Nov;53(11):1073-1083.

12. Nagao M, Fukuda A, Tsujimura M, Nishioka Y, Umeda M, Matsumura T, Seno H.

Hemophagocytic lymphohistiocytosis associated with hepatocellular carcinoma.
Clin J Gastroenterol. 2023 Oct;16(5):698-701.

13. Nagao M, Fukuda A, Nishioka Y, Kimura T.

Superior Mesenteric Venous Thrombosis Associated with Protein C Deficiency.
Intern Med. 2023 Oct 15;62(20):3087-3088.

14. Uemoto Y, Taura K, Yamada Y, Takeda H, Nakano S, Takai A, Haga H, Hatano E.

A Rare Case of Donor-Origin Intrahepatic Cholangiocarcinoma After Liver Transplantation for Hepatocellular Carcinoma: A Case Report.
Transplant Proc. 2023 Oct;55(8):1964-1967.

15. Sakurai T, Omori T, Tanaka H, Ito T, Ando K, Yamamura T, Nanjjo S, Osawa S, Takeda T, Watanabe K, Hiraga H, Yamamoto S, Ozeki K, Tanaka S, Tajiri H, Saruta M; SPREAD-J group.

Multicenter prospective registration study of efficacy and safety of capsule endoscopy in Crohn's disease in Japan (SPREAD-J study).
J Gastroenterol. 2023 Oct;58(10):1003-1014.

16. Watanabe K, Nojima M, Nakase H, Sato T, Matsuura M, Aoyama N, Kobayashi T, Sakuraba H, Nishishita M, Yokoyama K, Esaki M, Hirai F, Nagahori M, Nanjo S, Omori T, Tanida S, Yokoyama Y, Moriya K, Maemoto A, Handa O, Ohmiya N, Tsuchiya K, Shinzaki S, Kato S, Uraoka T, Tanaka H, Takatsu N, Nishida A, Umeno J, Nakamura M, Mishima Y, Fujiya M, Tsuchida K, Hiraoka S, Okabe M, Toyonaga T, Matsuoka K, Andoh A, Hirota Y, Hisamatsu T; J-COMBAT study group.

Trajectory analyses to identify persistently low responders to COVID-19 vaccination in patients with inflammatory bowel disease: a prospective multicentre controlled study, J-COMBAT.
J Gastroenterol. 2023 Oct;58(10):1015-1029.

17. Omatsu M, Nakanishi Y, Iwane K, Aoyama N, Duran A, Muta Y, Martinez-Ordonez A, Han Q, Agatsuma N, Mizukoshi K, Kawai M, Yamakawa G, Namikawa M, Hamada K, Fukunaga Y, Utsumi T, Sono M, Masuda T, Hata A, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Tsuda M, Maruno T, Kogame T, Kasashima H, Kakiuchi N, Nakagawa MM, Kawada K, Yashiro M, Maeda K, Saito Y, Matozaki T, Fukuda A, Kabashima K, Obama K, Ogawa S, Sheibani N, Diaz-Meco MT, Moscat J, Seno H.

THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer.
Nat Commun. 2023 Sep 25;14(1):5534.

18. Masuda T, Fukuda A, Yamakawa G, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Nagao M, Araki O, Yoshikawa T, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Masui T, Hatano E, Matsuzaki T, Noda M, Seno H.

Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis.
J Clin Invest. 2023 Sep 15;133(18):e161847.

19. Gulay KCM, Zhang X, Pantazopoulou V, Patel J, Esparza E, Pran Babu DS, Ogawa S, Weitz J, Ng I, Mose ES, Pu M, Engle DD, Lowy AM, Tiriac H.

Dual Inhibition of KRASG12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma.
Cancer Res. 2023 Sep 15;83(18):3001-3012.

20. Nakamura T, Nishikawa Y, Shiokawa M, Takeda H, Yokode M, Matsumoto S, Muramoto Y, Ota S, Yoshida H, Okada H, Kuwada T, Marui S, Matsumori T, Maruno T, Uza N, Kodama Y, Hatano E, Seno H.

ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway.
J Pathol. 2023 Sep;261(1):28-42.

21. Masui T, Nagai K, Anazawa T, Kasai Y, Yogo A, Yoshimura M, Mizowaki T, Uza N, Fukuda A, Matsumoto S, Kanai M, Isoda H, Kawaguchi Y, Uemoto S, Hatano E.

Safety and efficacy of neoadjuvant chemoradiotherapy with moderately hypofractionated intensity-modulated radiotherapy for resectable pancreatic cancer: A prospective, open-label, phase II study.
Cancer Med. 2023 Sep;12(18):18611-18621.

22. Nakayama S, Fukuda A, Kou T, Muto M, Seno H.

A case of unresectable ectopic acinar cell carcinoma developed in the portal vein in complete response to FOLFIRINOX therapy.
Clin J Gastroenterol. 2023 Aug;16(4):610-614.

23. Ueno M, Takabatake H, Itakura J, Fujita R, Kayahara T, Morimoto Y, Notohara K, Mizuno M.

Corticosteroid-refractory autoimmune hepatitis after COVID-19 vaccination: a case report and literature review.
Clin J Gastroenterol. 2023 Aug;16(4):554-558.

24. Ueno M, Fujiwara T, Tokumasu H, Mano T, Kayahara T, Takabatake H, Morimoto Y, Matsueda K, Fukuoka T, Mizuno M.

Real-world efficacy of antibiotic prophylaxis for upper gastrointestinal bleeding in cirrhotic patients in Japan.
J Gastroenterol. 2023 Aug;58(8):766-777.

25. Ueno A, Yokota M, Ueno M, Kawamoto K.

Colorectal cancer in adolescent and young adults: epidemiology in Japan and narrative review.
J Gastrointest Oncol. 2023 Aug 31;14(4):1856-1868.

26.Nishimura T, Kakiuchi N, Yoshida K, Sakurai T, Kataoka TR, Kondoh E, Chigusa Y, Kawai M, Sawada M, Inoue T, Takeuchi Y, Maeda H, Baba S, Shiozawa Y, Saiki R, Nakagawa MM, Nannya Y, Ochi Y, Hirano T, Nakagawa T, Inagaki-Kawata Y, Aoki K, Hirata M, Nanki K, Matano M, Saito M, Suzuki E, Takada M, Kawashima M, Kawaguchi K, Chiba K, Shiraishi Y, Takita J, Miyano S, Mandai M, Sato T, Takeuchi K, Haga H, Toi M, Ogawa S.

Evolutionary histories of breast cancer and related clones.
Nature. 2023 Aug;620(7974):607-614.

27. Yoshida H, Shiokawa M, Kuwada T, Muramoto Y, Ota S, Nishikawa Y, Maeda H, Kakiuchi N, Okamoto K, Yamazaki H, Yokode M, Nakamura T, Matsumoto S, Hirano T, Okada H, Marui S, Sogabe Y, Matsumori T, Mima A, Uza N, Eso Y, Takai A, Takahashi K, Ueda Y, Kodama Y, Chiba T, Seno H.

Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis.
J Gastroenterol. 2023 Aug;58(8):778-789.

28. Namikawa M, Fukuda A, Mizukoshi K, Iwane K, Kawai M, Yamakawa G, Omatsu M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Tsuruyama T, Taura K, Hatano E, Seno H.

Simultaneous activation of Kras-Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway.
J Pathol. 2023 Aug;260(4):478-492.

29. Utsumi T, Yamada Y, Diaz-Meco MT, Moscat J, Nakanishi Y.

Sessile serrated lesions with dysplasia: is it possible to nip them in the bud?
J Gastroenterol. 2023 Aug;58(8):705-717.

30. Kawamura T, Sekiguchi M, Takamaru H, Mizuguchi Y, Horiguchi G, Kato M, Kobayashi K, Sada M, Oda Y, Yokoyama A, Utsumi T, Tsuji Y, Ohki D, Takeuchi Y, Shichijo S, Ikematsu H, Matsuda K, Teramukai S, Kobayashi N, Matsuda T, Saito Y, Tanaka K.

"Endoscopic" adenoma detection rate as a quality indicator of colonoscopy: First report from the J-SCOUT study.
Dig Endosc. 2023 Jul;35(5):615-624.

31. Matsumori T, Uza N, Okada H, Shiokawa M, Maruno T, Kuwada T, Yoshida H, Yasuda M, Yamazaki H, Taura K, Hatano E, Kodama Y, Seno H.

Innovative method for the diagnosis of bile duct lesions using a novel tapered-tip sheath system to facilitate biliary biopsies.
Gastrointest Endosc. 2023 Jul;98(1):43-50.

32. Matsumori T, Uza N, Shiokawa M, Maruno T, Seno H.

Concomitant occurrence of pancreatic cancer during long-term follow-up for serous neoplasms.
J Med Ultrason (2001). 2023 Jul;50(3):451-452.

33. Nannya Y, Tobiasson M, Sato S, Bernard E, Ohtake S, Takeda J, Creignou M, Zhao L, Kusakabe M, Shibata Y, Nakamura N, Watanabe M, Hiramoto N, Shiozawa Y, Shiraishi Y, Tanaka H, Yoshida K, Kakiuchi N, Makishima H, Nakagawa M, Usuki K, Watanabe M, Imada K, Handa H, Taguchi M, Kiguchi T, Ohyashiki K, Ishikawa T, Takaori-Kondo A, Tsurumi H, Kasahara S, Chiba S, Naoe T, Miyano S, Papaemanuil E, Miyazaki Y, Hellstrom-Lindberg E, Ogawa S.

Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms.
Blood Adv. 2023 Jul 25;7(14):3624-3636.

34. Araki O, Tsuda M, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Yoshikawa T, Nagao M, Ogawa S, Masuo K, Goto N, Muta Y, Hiramatsu Y, Maruno T, Nakanishi Y, Koyasu S, Masui T, Hatano E, Saur D, Fukuda A, Seno H.

Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway.
Oncogene. 2023 Jun;42(26):2139-2152.

35. Nakayama S, Matsumura K, Fukuda A, Seno H.

A case of dedifferentiated liposarcoma of the descending colon.
Clin J Gastroenterol. 2023 Jun;16(3):361-365.

36. Uchida Y, Yoh T, Fukui A, Takai A, Hatano E.

Complete Metabolic Response by 18 F-FDG PET/CT to Atezolizumab Plus Bevacizumab in Patients With Advanced Hepatocellular Carcinoma.
Clin Nucl Med. 2023 May 1;48(5):417-419.

37. Yogo A, Masui T, Takaishi S, Masuo K, Chen R, Kasai Y, Nagai K, Anazawa T, Watanabe S, Sakamoto S, Watanabe A, Inagaki R, Nakagawa MM, Ogawa S, Seno H, Uemoto S, Hatano E.

Inhibition of Dopamine Receptor D1 Signaling Promotes Human Bile Duct Cancer Progression via WNT signaling.
Cancer Sci. 2023 Apr;114(4):1324-1336.

38. Aoyama N, Wada M, Taniguchi Y, Inokuma T, Nakanishi Y, Fukuda A, Seno H.

A case of neuroendocrine neoplasm of the minor duodenal papilla.
Clin J Gastroenterol. 2023 Apr;16(2):171-179.

39. Mizuno K, Kishimoto Y, Kawai Y, Fujimura S, Iwanaga K, Mizuno K, Shimizu T, Yokoyama A, Nikaido M, Hirohashi K, Muto M, Seno H, Tateya I, Omori K.

A prospective evaluation of postoperative swallowing function and dysphagia following endoscopic laryngopharyngeal surgery.
Int J Clin Oncol. 2023 Apr;28(4):521-530.

40. Kumagai K, Shimizu T, Nikaido M, Hirano T, Kakiuchi N, Takeuchi Y, Minamiguchi S, Sakurai T, Teramura M, Utsumi T, Hiramatsu Y, Nakanishi Y, Takai A, Miyamoto S, Ogawa S, Seno H.

On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma.
J Pathol. 2023 Apr;259(4):362-368.

41. Nagao M, Fukuda A.

The role of stromal BMP/CXCL12 signaling axis in serrated polyp development.
J Gastroenterol. 2023 Apr;58(4):429-430.

42. Kondo T, Kanai M, Matsubara J, Yamaguchi D, Ura T, Kou T, Itani T, Nomura M, Funakoshi T, Yokoyama A, Doi K, Tamaoki M, Yoshimura M, Uza N, Yamada T, Masui T, Minamiguchi S, Matsumoto S, Ishikawa H, Muto M.

Association between homologous recombination gene variants and efficacy of oxaliplatin-based chemotherapy in advanced pancreatic cancer: prospective multicenter observational study.
Med Oncol. 2023 Apr 11;40(5):144.

43. Nagao M, Mizukoshi K, Nakayama S, Namikawa M, Hiramatsu Y, Maruno T, Nakanishi Y, Tsuruyama T, Fukuda A, Seno H.

p53 protects against formation of extrahepatic biliary precancerous lesions in the context of oncogenic Kras.
Oncotarget. 2023 Mar 31;14:276-279.

44. Sakamoto Y, Sasaki K, Omatsu M, Hamada K, Nakanishi Y, Itatani Y, Kawada K, Obama K, Seno H, Iwai K.

Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation.
J Pathol. 2023 Mar;259(3):304-317.

45. Takahiko Ito, Daisuke Takayanagi, Shigeki Sekine, Taiki Hashimoto, Yoko Shimada, Maiko Matsuda, Masayoshi Yamada, Ryuji Hamamoto, Tomoyasu Kato, Dai Shida, Yukihide Kanemitsu, Narikazu Boku, Takashi Kohno, Atsuo Takashima, Kouya Shiraishi

Comparison of clinicopathological and genomic profiles in anal squamous cell carcinoma between Japanese and Caucasian cohorts
Sci Rep. 2023 Mar 3;13(1):3587.

46. Martinez-Ordonez A, Duran A, Ruiz-Martinez M, Cid-Diaz T, Zhang X, Han Q, Kinoshita H, Muta Y, Linares JF, Kasashima H, Nakanishi Y, Omar M, Nishimura S, Avila L, Yashiro M, Maeda K, Pannellini T, Pigazzi A, Inghirami G, Marchionni L, Sigal D, Diaz-Meco MT, Moscat J.

Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer.
Cancer Cell. 2023 Feb 13;41(2):252-271.

47. Oe N, Takeda H, Eso Y, Takai A, Marusawa H.

Evolutional transition of HBV genome during the persistent infection determined by single-molecule real-time sequencing.
Hepatol Commun. 2023 Feb 27;7(3):e0047.

48. Okamura T, Hamaguchi M, Hasegawa Y, Hashimoto Y, Majima S, Senmaru T, Ushigome E, Nakanishi N, Asano M, Yamazaki M, Sasano R, Nakanishi Y, Seno H, Takano H, Fukui M.

Oral Exposure to Polystyrene Microplastics of Mice on a Normal or High-Fat Diet and Intestinal and Metabolic Outcomes.
Environ Health Perspect. 2023 Feb;131(2):27006.

49. Umemoto A, Kuwada T, Murata K, Shiokawa M, Ota S, Murotani Y, Itamoto A, Nishitani K, Yoshitomi H, Fujii T, Onishi A, Onizawa H, Murakami K, Tanaka M, Ito H, Seno H, Morinobu A, Matsuda S.

Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis.
Arthritis Res Ther. 2023 Feb 17;25(1):25.

50. Makishima H, Saiki R, Nannya Y, Korotev S, Gurnari C, Takeda J, Momozawa Y, Best S, Krishnamurthy P, Yoshizato T, Atsuta Y, Shiozawa Y, Iijima-Yamashita Y, Yoshida K, Shiraishi Y, Nagata Y, Kakiuchi N, Onizuka M, Chiba K, Tanaka H, Kon A, Ochi Y, Nakagawa MM, Okuda R, Mori T, Yoda A, Itonaga H, Miyazaki Y, Sanada M, Ishikawa T, Chiba S, Tsurumi H, Kasahara S, Muller-Tidow C, Takaori-Kondo A, Ohyashiki K, Kiguchi T, Matsuda F, Jansen JH, Polprasert C, Blombery P, Kamatani Y, Miyano S, Malcovati L, Haferlach T, Kubo M, Cazzola M, Kulasekararaj AG, Godley LA, Maciejewski JP, Ogawa S.

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.
Blood. 2023 Feb 2;141(5):534-549.

51. Nagao M, Fukuda A, Seno H.

The role of Kras and canonical Wnt pathways for tumorigenesis of extrahepatic biliary system.
Oncotarget. 2023 Jan 26;14:54-56.

52. Ueda T, Shiina S, Iriguchi S, Terakura S, Kawai Y, Kabai R, Sakamoto S, Watanabe A, Ohara K, Wang B, Xu H, Minagawa A, Hotta A, Woltjen K, Uemura Y, Kodama Y, Seno H, Nakatsura T, Tamada K, Kaneko S.

Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells.
Nat Biomed Eng. 2023 Jan;7(1):24-37.

53. Inoue G, Yamamoto S, Koh N, Kuwada T, Nakanishi Y, Takahashi K, Seno H.

Unusual case of severe diarrhoea.
Gut. 2023 Jan;72(1):48-152.

54. Yamawaka T, Kitamoto H, Nojima M, Kazama T, Wagatsuma K, Ishigami K, Yamamoto S, Honzawa Y, Matsuura M, Seno H, Nakase H.

The association between antigenemia, histology with immunohistochemistry, and mucosal PCR in the diagnosis of ulcerative colitis with concomitant human cytomegalovirus infection.
J Gastroenterol. 2023 Jan;58(1):44-52.

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