京都大学大学院医学研究科・消化器内科学 Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine

研究業績 2024年

Publication 2024

臨床をすべての中心として、ひとつひとつの症例を大切にしながら、日々研究に教育に勤しんでいます。その過程で、教室メンバーが関わってきた論文をご紹介します。

1. Nagao M, Fukuda A, Kashima H, Matsuyama S, Iimori K, Nakayama S, Mizukoshi K, Kawai M, Yamakawa G, Omatsu M, Namikawa M, Masuda T, Hiramatsu Y, Muta Y, Maruno T, Nakanishi Y, Tsuruyama T, Seno H.
Cholangiocyte organoids for disease, cancer, and regenerative medicine.
Eur J Cell Biol. 2024 Dec 19;104(1):151472. doi: 10.1016/j.ejcb.2024.151472
2. Matsuyama S, Fukuda A, Yamakawa G, Ueo T, Seno H.
A Case of Severe Post-Biopsy Bleeding and Perforation in Gastric Amyloidosis.
JGH Open. 2024 Dec 3;8(12):e70065. doi: 10.1002/jgh3.70065.
3. Hiramatsu Y, Utsumi T, Ikeda M, Seno H.
Rapid Progression of a Sessile Serrated Lesion.
Intern Med. 2024 Dec 1;63(23):3255-3256. doi: 10.2169/internalmedicine.3415-24.
4. Ueno M, Takeda H, Takai A, Morimura H, Nishijima N, Iwamoto S, Okuyama S, Umeda M, Seta T, Ikeda A, Goto T, Miyamoto S, Kayahara T, Uenoyama Y, Matsumura K, Nakano S, Mishima M, Inuzuka T, Eso Y, Takahashi K, Marusawa H, Osaki Y, Hatano E, Seno H.
CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study.
J Gastroenterol. 2024 Dec;59(12):1107-1118. doi: 10.1007/s00535-024-02150-7.
5. Sawada K, Matsumori T, Nishikawa Y, Maruno T, Shiokawa M, Uza N, Seno H.
Removal of a torn biliary stent fragment using a novel tapered-tip sheath system.
Endoscopy. 2024 Dec;56(S 01):E374-E376. doi: 10.1055/a-2304-8328.
6. Yanaidani T, Matsumori T, Yokode M, Muramoto Y, Shiokawa M, Uza N, Seno H.
Usefulness of a novel drill dilator in removing a migrated biliary plastic internal stent.
Endoscopy. 2024 Dec;56(S 01):E311-E312. doi: 10.1055/a-2291-9255.
7. Mori Y, Iwano K, Ito R, Azuma S, Morita T, Kuriyama K, Yazumi S.
Successful endoscopic ultrasound-guided drainage using contrast-enhanced harmonic imaging.
Endoscopy. 2024 Dec;56(S 01):E1016-E1017. doi: 10.1055/a-2436-6706../
8. Ogura J, Yamanoi K, Ishida K, Nakamura E, Ito S, Aoyama N, Nakanishi Y, Menju T, Kawaguchi K, Hosoe Y, Taki M, Murakami R, Yamaguchi K, Hamanishi J, Mandai M.
A stearate-rich diet and oleate restriction directly inhibit tumor growth via the unfolded protein response.
Exp Mol Med. 2024 Dec;56(12):2659-2672. doi: 10.1038/s12276-024-01356-2.
9. Yaku H, Takahashi K, Okada H, Kobiyama K, Shiokawa M, Uza N, Kodama Y, Ishii KJ, Seno H.
Near-infrared photoimmunotherapy as a complementary modality to in situ vaccine in a preclinical pancreatic cancer model.
Biochem Biophys Res Commun. 2024 Dec 10;737:150534. doi: 10.1016/j.bbrc.2024.150534.
10. Yamada A, Doi Y, Minamiguchi S, Kondo T, Sunami T, Horimatsu T, Hamanishi J, Mandai M, Hatano E, Kobayashi T, Hisamori S, Obama K, Seno H, Haga H, Torishima M, Murakami H, Nakajima T, Yamada T, Kosugi S, Sugano K, Muto M.
Lynch syndrome screening in patients with young-onset extra-colorectal Lynch syndrome-associated cancers.
Int J Clin Oncol. 2024 Nov;29(11):1696-1703. doi: 10.1007/s10147-024-02609-w
11. Yamamoto M, Kanda M, Mizushima I, Kanno A, Umemura T, Ikeura T, Kodama Y, Dobashi H, Tanaka Y, Masamune A, Moriyama M, Saeki T, Matsui S, Origuchi T, Masaki Y, Asada M, Umehara H, Seno H, Naitoh I, Yamamoto S, Iwasaki E, Kubota K, Tanoue S, Nishino T, Tsuboi H, Matsumoto Y, Isayama H, Goto H, Notohara K, Uchida K, Kawabe K, Yamada K, Kasashima S, Takahira M, Sato Y, Kawachi I, Yamaguchi I, Okazaki K, Nakamura S, Matsuda F, Ishikawa H, Kawano M; Patient Registry Committee, Research Program for Intractable Disease by the Ministry of Health, Labour and Welfare (MHLW), Japan; *Other than the co-authors, the members of Patient Registry Committee, Research Program for Intractable Disease by the Ministry of Health, Labour and Welfare (MHLW), Japan are as follows: Kensuke Yokoyama (Jichi Medical University).
Clinical profile of IgG4-related disease in Japan based on the rare disease data registry.
Immunol Med. 2024 Nov 28:1-11. doi: 10.1080/25785826.2024.2430812.
12. Mishima M, Takai A, Takeda H, Iguchi E, Nakano S, Fujii Y, Ueno M, Ito T, Teramura M, Eso Y, Shimizu T, Maruno T, Hidema S, Nishimori K, Marusawa H, Hatano E, Seno H.
TERT upregulation promotes cell proliferation via degradation of p21 and increases carcinogenic potential.
J Pathol. 2024 Nov;264(3):318-331. doi: 10.1002/path.6351.
13. Sono M, Iimori K, Nagao M, Ogawa S, Maruno T, Nakanishi Y, Anazawa T, Nagai K, Masui T, Mori H, Hosomi K, Kunisawa J, Yokota H, Tanaka Y, Ohno H, Hatano E, Fukuda A, Seno H.
Reduction of butyrate-producing bacteria in the gut microbiome of Japanese patients with pancreatic cancer.
Pancreatology. 2024 Nov;24(7):1031-1039. doi: 10.1016/j.pan.2024.09.002.
14. Okamoto M, Okamura R, Itatani Y, Aisu Y, Kinoshita H, Hoshino N, Maekawa H, Sakamoto T, Kasahara K, Okumura S, Nishigori T, Hisamori S, Tsunoda S, Hida K, Nikaido M, Hiramatsu Y, Teramoto Y, Nagayama S, Obama K.
Low-grade appendiceal mucinous neoplasm penetrating sigmoid colon: A case report.
Asian J Endosc Surg. 2024 Oct;17(4):e13368. doi: 10.1111/ases.13368.
15. Tamagawa H, Fujii M, Togasaki K, Seino T, Kawasaki S, Takano A, Toshimitsu K, Takahashi S, Ohta Y, Matano M, Kawasaki K, Machida Y, Sekine S, Machinaga A, Sasai K, Kodama Y, Kakiuchi N, Ogawa S, Hirano T, Seno H, Kitago M, Kitagawa Y, Iwasaki E, Kanai T, Sato T.
Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma.
Nat Cell Biol. 2024 Oct;26(10):1759-1772. doi: 10.1038/s41556-024-01498-5.
16. Kawai M, Fukuda A, Otomo R, Obata S, Minaga K, Asada M, Umemura A, Uenoyama Y, Hieda N, Morita T, Minami R, Marui S, Yamauchi Y, Nakai Y, Takada Y, Ikuta K, Yoshioka T, Mizukoshi K, Iwane K, Yamakawa G, Namikawa M, Sono M, Nagao M, Maruno T, Nakanishi Y, Hirai M, Kanda N, Shio S, Itani T, Fujii S, Kimura T, Matsumura K, Ohana M, Yazumi S, Kawanami C, Yamashita Y, Marusawa H, Watanabe T, Ito Y, Kudo M, Seno H.
Early detection of pancreatic cancer by comprehensive serum miRNA sequencing with automated machine learning.
Br J Cancer. 2024 Oct;131(7):1158-1168. doi: 10.1038/s41416-024-02794-5.
17. Hirata A, Matsumori T, Yasuda M, Nishikawa Y, Shiokawa M, Uza N, Seno H.
A rare case of acute obstructive suppurative pancreatic ductitis (AOSPD) which developed pyogenic spondylitis.
Clin J Gastroenterol. 2024 Oct;17(5):982-988. doi: 10.1007/s12328-024-02004-y.
18. Wakazono E, Taki M, Watanabe K, Yamanoi K, Murakami R, Kakiuchi N, Yamaguchi K, Hamanishi J, Minamiguchi S, Ogawa S, Mandai M.
A case report of mucinous borderline ovarian tumor with recurrence as invasive carcinoma with high copy number alterations.
Int Cancer Conf J. 2024 Sep 17;13(4):520-524. doi: 10.1007/s13691-024-00722-1.
19. Kinoshita H, Martinez-Ordonez A, Cid-Diaz T, Han Q, Duran A, Muta Y, Zhang X, Linares JF, Nakanishi Y, Kasashima H, Yashiro M, Maeda K, Albaladejo-Gonzalez A, Torres-Moreno D, Garcia-Solano J, Conesa-Zamora P, Inghirami G, Diaz-Meco MT, Moscat J.
Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation.
Dev Cell. 2024 Aug 5;59(15):1972-1987.e8. doi: 10.1016/j.devcel.2024.05.001.
20. Ito T, Takeuchi Y, Mizuno K, Imai M, Yoshimaru Y, Abe K, Abe M, Matsuura T, Yokode M, Shiokawa M, Kodama Y, Komuta M, Harada K, Tanaka A.
Diagnostic guide for immune checkpoint inhibitor-induced liver injury.
Hepatol Res. 2024 Aug;54(8):719-726. doi: 10.1111/hepr.14078.
21. Pereye OB, Nakagawa Y, Sato T, Fukunaka A, Aoyama S, Nishida Y, Mizutani W, Kobayashi N, Morishita Y, Oyama T, Kawabata-Iwakawa R, Watada H, Mizukami H, Fukuda A, Fujitani Y.
Identification of Ppy-lineage cells as a novel origin of pancreatic ductal adenocarcinoma.
J Pathol. 2024 Aug;263(4-5):429-441. doi: 10.1002/path.6295.
22. Nakayama S, Fukuda A, Nishikawa S, Hirata A, Teramura M, Takai A, Seno H.
A case of spontaneous acute obstructive suppurative pancreatic ductitis associated with intraductal papillary mucinous neoplasms.
Clin J Gastroenterol. 2024 Aug;17(4):760-764. doi: 10.1007/s12328-024-01973-4.
23. Matsuyama S, Fukuda A, Okano A, Ohana M.
Atypical Image Change of Hepatic Mucinous Cystic Neoplasm.
Intern Med. 2024 Jul 1;63(13):1963-1964. doi: 10.2169/internalmedicine.2780-23.
24. Masui H, Kawada K, Itatani Y, Hirai H, Nakanishi Y, Kiyasu Y, Hanada K, Okamoto M, Hirata W, Nishikawa Y, Sugimoto N, Tamura T, Sakai Y, Obama K.
Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment.
Br J Cancer. 2024 Jul;131(1):63-76. doi: 10.1038/s41416-024-02710-x.
25. Tanifuji A, Ohfuji S, Matsumoto K, Abe M, Komori A, Takahashi A, Kawata K, Sato K, Joshita S, Umemura T, Ueno M, Nakayama N, Kakisaka K, Arinaga-Hino T, Ito K, Kanai S, Miura R, Arizumi T, Asaoka Y, Ito T, Shimizu T, Yoshida H, Ohta M, Mizuno S, Isayama H, Morimoto Y, Mochida S, Ohira H, Tanaka A.
Safety and effectiveness of SARS-CoV-2 vaccines for patients with intractable hepatobiliary diseases: A multicenter, questionnaire-based, cross-sectional study.
Hepatol Res. 2024 Jul;54(7):706-715. doi: 10.1111/hepr.14018.
26. Maeda H, Kakiuchi N.
Clonal expansion in normal tissues.
Cancer Sci. 2024 Jul;115(7):2117-2124. doi: 10.1111/cas.16183.
27. Yamada S, Honzawa Y, Yamamoto S, Matsuura M, Kitamoto H, Okabe M, Kakiuchi N, Toyonaga T, Kobayashi T, Hibi T, Seno H, Nakase H.
Single Nucleotide Polymorphisms of the MEFV Gene E148Q Are Highly Associated With Disease Phenotype in Crohn's Disease.
Inflamm Bowel Dis. 2024 Jun 3;30(6):970-980. doi: 10.1093/ibd/izad259.
28. Tanaka A, Tsuji K, Komiyama Y, Tsuruya K, Kakisaka K, Tsutsui A, Ichimoto K, Ueno M, Okazaki Y, Kamimura H, Takai A, Yamashiki N, Ito T, Watanabe M, Abe M, Harada KI, Kagawa T.
RECAM-J 2023-Validation and development of the Japanese version of RECAM for the diagnosis of drug-induced liver injury.
Hepatol Res. 2024 Jun;54(6):503-512. doi: 10.1111/hepr.14046.
29. Yokode M, Shiokawa M, Kawakami H, Kuwada T, Nishikawa Y, Muramoto Y, Kitamoto H, Okabe M, Yamazaki H, Okamoto N, Morita T, Ohno K, Nakanishi R, Takimoto I, Yasuda M, Chikugo K, Matsumoto S, Yoshida H, Ota S, Nakamura T, Okada H, Hirano T, Kakiuchi N, Matsumori T, Yamamoto S, Uza N, Ooi M, Kodama Y, Chiba T, Hayashi H, Seno H.
Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis.
Br J Cancer. 2024 May;130(9):1552-1560. doi: 10.1038/s41416-024-02647-1.
30. Ishikawa Y, Yoshida H, Yoshifuji H, Ohmura K, Origuchi T, Ishii T, Mimori T, Morinobu A, Shiokawa M, Terao C.
Anti-integrin αvβ6 antibody in Takayasu arteritis patients with or without ulcerative colitis.
Front Immunol. 2024 May 9;15:1387516. doi: 10.3389/fimmu.2024.1387516.
31. Takikawa T, Kikuta K, Sano T, Ikeura T, Fujimori N, Umemura T, Naitoh I, Nakase H, Isayama H, Kanno A, Kamata K, Kodama Y, Inoue D, Ido A, Ueki T, Seno H, Yasuda H, Iwasaki E, Nishino T, Kubota K, Arizumi T, Tanaka A, Uchida K, Matsumoto R, Hamada S, Nakamura S, Okazaki K, Takeyama Y, Masamune A; Japan Pancreatitis Study Group for AIP.
Maintenance steroid therapy is associated with decreased risk of malignancy and better prognosis of patients with autoimmune pancreatitis: A multicenter cohort study in Japan.
Pancreatology. 2024 May;24(3):335-342. doi: 10.1016/j.pan.2024.01.008.
32. Matsuyama S, Fukuda A, Ueo T, Ohana M.
Intussusception of Mesenteric Liposarcoma into the Ascending Colon.
Intern Med. 2024 May 15;63(10):1517-1518. doi: 10.2169/internalmedicine.2670-23.
33. Makino K, Ishii T, Takeda H, Saito Y, Fujiwara Y, Fujimoto M, Ito T, Wakama S, Kumagai K, Munekage F, Horie H, Tomofuji K, Oshima Y, Uebayashi EY, Kawai T, Ogiso S, Fukumitsu K, Takai A, Seno H, Hatano E.
Integrated analyses of the genetic and clinicopathological features of cholangiolocarcinoma: cholangiolocarcinoma may be characterized by mismatch-repair deficiency.
J Pathol. 2024 May;263(1):32-46.
34. Agatsuma N, Utsumi T, Nishikawa Y, Horimatsu T, Seta T, Yamashita Y, Tanaka Y, Inoue T, Nakanishi Y, Shimizu T, Ohno M, Fukushima A, Nakayama T, Seno H.
Stage at diagnosis of colorectal cancer through diagnostic route: Who should be screened?
World J Gastroenterol. 2024 Mar 14;30(10):1368-1376. doi: 10.3748/wjg.v30.i10.1368.
35. Goto N, Westcott PMK, Goto S, Imada S, Taylor MS, Eng G, Braverman J, Deshpande V, Jacks T, Agudo J, Yilmaz OH.
SOX17 enables immune evasion of early colorectal adenomas and cancers.
Nature. 2024 Mar;627(8004):636-645. doi: 10.1038/s41586-024-07135-3.
36. Kubota H, Ueno H, Tasaka K, Isobe T, Saida S, Kato I, Umeda K, Hiwatari M, Hasegawa D, Imamura T, Kakiuchi N, Nannya Y, Ogawa S, Hiramatsu H, Takita J.
RNA-seq-based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia.
Blood Adv. 2024 Mar 12;8(5):1258-1271. doi: 10.1182/bloodadvances.2023011583.
37. Ishida Y, Murata T, Kakiuchi N, Ogawa S, Kabashima K.
Emergence of multiple revertant keratinocyte clones in a patient with KID syndrome.
J Eur Acad Dermatol Venereol. 2024 Mar;38(3):e285-e287. doi: 10.1111/jdv.19595.
38. D'Ambrosio A, Bressan D, Ferracci E, Carbone F, Mule P, Rossi F, Barbieri C, Sorrenti E, Fiaccadori G, Detone T, Vezzoli E, Bianchi S, Sartori C, Corso S, Fukuda A, Bertalot G, Falqui A, Barbareschi M, Romanel A, Pasini D, Chiacchiera F.
Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations.
Sci Adv. 2024 Mar 15;10(11):eadh4435. doi: 10.1126/sciadv.adh4435.
39. Bae SH, Chun SJ, Chung JH, Kim E, Kang JK, Jang WI, Moon JE, Roquette I, Mirabel X, Kimura T, Ueno M, Su TS, Tree AC, Guckenberger M, Lo SS, Scorsetti M, Slotman BJ, Kotecha R, Sahgal A, Louie AV, Kim MS.
Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: Meta-Analysis and International Stereotactic Radiosurgery Society Practice Guidelines.
Int J Radiat Oncol Biol Phys. 2024 Feb 1;118(2):337-351. doi: 10.1016/j.ijrobp.2023.08.015.
40. Yanaidani T, Matsumori T, Muramoto Y, Nishikawa Y, Maruno T, Shiokawa M, Uza N, Seno H.
Pancreatic stent removal with a novel drill dilator.
VideoGIE. 2024 Feb 3;9(5):243-246. doi: 10.1016/j.vgie.2024.01.007.
41. Matsuyama S, Fukuda A, Ohana M.
Gastrointestinal: Lupus enteritis with duodenojejunal fistula causing intestinal obstruction and gastrointestinal perforation.
J Gastroenterol Hepatol. 2024 Feb;39(2):220-221. doi: 10.1111/jgh.16373.
42. Matsuyama S, Fukuda A, Matsumoto A, Eguchi H, Ueo T, Ohana M, Seno H.
Sporadic gastric juvenile polyposis with a novel SMAD4 nonsense mutation in a mosaic pattern.
Clin J Gastroenterol. 2024 Feb;17(1):23-28.
43. Kawamura T, Sekiguchi M, Takamaru H, Mizuguchi Y, Horiguchi G, Toyoizumi H, Kato M, Kobayashi K, Sada M, Oda Y, Yokoyama A, Utsumi T, Tsuji Y, Ohki D, Takeuchi Y, Shichijo S, Ikematsu H, Matsuda K, Teramukai S, Kobayashi N, Matsuda T, Saito Y, Tanaka K.
Endoscopist-related factors affecting adenoma detection during colonoscopy: Data from the J-SCOUT study.
Dig Endosc. 2024 Jan;36(1):51-58. doi: 10.1111/den.14721.
44. Ito T, Ishii T, Takeda H, Sumiyoshi S, Tomofuji K, Wakama S, Makino K, Horie H, Kumagai K, Takai A, Uebayashi EY, Ogiso S, Fukumitsu K, Haga H, Seno H, Hatano E.
Comprehensive analyses of the clinicopathological features and genomic mutations of combined hepatocellular-cholangiocarcinoma.
Hepatol Res. 2024 Jan;54(1):103-115.
45. Nishikawa Y, Agatsuma N, Utsumi T, Funakoshi T, Mori Y, Nakamura Y, Hoshino N, Horimatsu T, Saito T, Kashihara S, Fukuyoshi J, Goto R, Toi M, Takahashi Y, Nakayama T.
Medical care costs according to the stage and subtype of breast cancer in a municipal setting: a case study of Hachioji City, Japan.
Breast Cancer. 2024 Jan;31(1):105-115. doi: 10.1007/s12282-023-01517-7.
京都大学大学院医学研究科 京都大学医学部附属病院 スッキリプロジェクト 同門会の方へ

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